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Amin El-Heliebi: "Investigating Tumor Dissemination by Spatial Transcriptomics"
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Cancer tissue is a complex composition of multiple cell types, including normal, neoplastic, and reactive cells (McManus et al., 2014). ln advanced disease, tumor cells can leave the primary tumor and form metastasis (EI-Heliebi et al., Nucleic Acid Nanotheranostics 2019). Metastatic disease is the major cause for cancer related death. To understand the process of metastasis formation, it is crucial to comprehend the mechanisms of tumor growth, invasion, and dissemination.
ln this webinar, I will introduce our spatial transcriptomics approach to investigate predictive biomarkers in colon cancer and disease relapse. I will show an imaging-based in situ sequencing approach that enables the visualization and quantification of greater than 200 different RNA transcripts directly on formalin fixed and paraffin embedded cancer tissue.
Featured Speaker: Amin El-Heliebi (Professor)
Professor Amin El-Heliebi was educated in Graz, Stockholm and Buenos Aires and was appointed Research Professor 2021 at the Medical University of Graz, Austria. His research focus lies in molecular biomarkers, cancer research, liquid biopsy, tumor biology, and spatial transcriptomics. His overarching research question deals with understanding tumor dissemination. His research group investigates liquid biopsies, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). Their overall aim is to track and trace liquid biopsies back to the originating tumor mass and identify the mechanisms involved in spreading of metastatic disease.